C. ELEGANS CLASP/CLS-2 NEGATIVELY REGULATES MEMBRANE INGRESSION THROUGHOUT THE OOCYTE CORTEX AND IS REQUIRED FOR POLAR BODY EXTRUSION.

C. elegans CLASP/CLS-2 negatively regulates membrane ingression throughout the oocyte cortex and is required for polar body extrusion.

The requirements for oocyte meiotic cytokinesis during polar body extrusion are not well understood.In particular, the relationship between the oocyte meiotic spindle and polar body contractile ring dynamics remains largely unknown.We have used live cell imaging and spindle assembly defective mutants lacking the function of CLASP/CLS-2, kinesin-12/

read more



Cohort description: The Danish study of Functional Disorders

Thomas Meinertz Dantoft,1 Jeanette Frost Ebstrup,1 Allan Linneberg,1–3 Sine Skovbjerg,1 Anja Lykke Madsen,1 Jesper Mehlsen,4 Louise Brinth,4 Lene Falgaard Eplov,5 Tina Wisbech Carstensen,6,7 Andreas Schroder,6,7 Per Klausen Fink,6,7 Erik Lykke Mortensen,8 Torben Hansen,9 Oluf Pedersen,9 Torben Jørgensen1,10,11 1Research Centr

read more